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Literature summary for 2.7.11.3 extracted from

  • Beg, Z.H.; Stonik, J.A.; Brewer, B.
    Characterization and regulation of reductase kinase, a protein kinase that modulates the enzymic activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (1979), Proc. Natl. Acad. Sci. USA, 76, 4375-4379.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.3

Activating Compound

Activating Compound Comment Organism Structure
additional information cAMP-independent enzyme Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
poly(Arg) casein as substrate Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Rattus norvegicus 5829
-
microsome
-
 Rattus norvegicus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ requirement, actual substrate: MgATP Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
380000
-
 gel filtration Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] Rattus norvegicus involved in regulation cascade of hydroxymethylglutaryl-CoA reductase, EC 1.1.1.34 ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
 ?
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] Rattus norvegicus phosphorylation activates EC 2.7.1.109 ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
cytosolic enzyme Rattus norvegicus
partial Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + casein
-
 Rattus norvegicus ?
-
 ?
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] No substrate is hydroxymethylglutaryl-CoA reductase (NADPH) Rattus norvegicus ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
 ?
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] involved in regulation cascade of hydroxymethylglutaryl-CoA reductase, EC 1.1.1.34 Rattus norvegicus ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
 ?
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] phosphorylation activates EC 2.7.1.109 Rattus norvegicus ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
 ?
ATP + histone 2A poor substrate Rattus norvegicus ?
-
 ?
ATP + phosvitin slight activity Rattus norvegicus ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Rattus norvegicus
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Rattus norvegicus

pI Value

Organism Comment pI Value Maximum pI Value
Rattus norvegicus isoelectric focusing 5.9 5.6